3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide
LDC000067
CAS: 1073485-20-7
Molecular Formula: C18H18N4O3S
3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide - Names and Identifiers
3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide - Physico-chemical Properties
| Molecular Formula | C18H18N4O3S |
| Molar Mass | 370.43 |
| Density | 1.360±0.06 g/cm3(Predicted) |
| Boling Point | 604.1±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 47 mg/mL |
| pKa | 10.27±0.60(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| In vitro study | LDC000067 reduces mESCs by Ser2-P, induces p53 activation, and leads to apoptosis. In addition, LDC067 also dose-dependently inhibited the de novo RNA synthesis of P-TEFb-dependent cellular genes. |
3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.7 ml | 13.498 ml | 26.996 ml |
| 5 mM | 0.54 ml | 2.7 ml | 5.399 ml |
| 10 mM | 0.27 ml | 1.35 ml | 2.7 ml |
| 5 mM | 0.054 ml | 0.27 ml | 0.54 ml |
Last Update：2024-01-02 23:10:35
3-[[6-(2-methoxyphenyl)-4-pyrimidinyl]amino]-benzenemethanesulfonamide - Reference Information
| biological activity | LDC000067 (LDC067) is a highly selective CDK9 inhibitor with IC50 of 44 nM, which is 55/125/210/227/ >227 times higher than the selectivity of CDK2/1/4/6/7 respectively. |
| target | TargetValue CDK9 (cell-free assay) 44 nM CDK2 (cell-free assay) 2.441 μM |
| Target | Value |
| CDK9 (Cell-free assay) | 44 nM |
| CDK2 (Cell-free assay) | 2.441 μM |
| in vitro study | LDC000067 reduce Ser2-P in mESCs, induce p53 activation, and lead to apoptosis. In addition, LDC067 also dose-dependently inhibits RNA de novo synthesis of P-TEFb-dependent cellular genes. |
Last Update：2024-04-09 21:11:58
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Product Name: LDC000067 Visit Supplier Webpage Request for quotation
CAS: 1073485-20-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 1073485-20-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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